A point mutation in the last intron responsible for increased expression and transforming activity of the c-Ha-ras oncogene
- 1 July 1988
- journal article
- Published by Springer Science and Business Media LLC in Nature
- Vol. 334 (6178), 119-124
- https://doi.org/10.1038/334119a0
Abstract
The T24/EJ allele of the Ha-ras proto-oncogene owes its powerful oncogenic activity not merely to the well documented mutation that perturbs the structure of the encoded polypeptide, but in addition to a second single nucleotide alteration in an intron that causes a tenfold increase in expression. This effect on expression is maintained upon transfer of the surrounding DNA to a heterologous gene, and as such defines a novel regulatory element.Keywords
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