Stressed out: the skeletal muscle ryanodine receptor as a target of stress
- 1 February 2008
- journal article
- review article
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 118 (2), 445-453
- https://doi.org/10.1172/jci34006
Abstract
Over the past century, understanding the mechanisms underlying muscle fatigue and weakness has been the focus of much investigation. However, the dominant theory in the field, that lactic acidosis causes muscle fatigue, is unlikely to tell the whole story. Recently, dysregulation of sarcoplasmic reticulum (SR) Ca2+ release has been associated with impaired muscle function induced by a wide range of stressors, from dystrophy to heart failure to muscle fatigue. Here, we address current understandings of the altered regulation of SR Ca2+ release during chronic stress, focusing on the role of the SR Ca2+ release channel known as the type 1 ryanodine receptor.This publication has 124 references indexed in Scilit:
- Pathophysiology of Duchenne Muscular Dystrophy: Current HypothesesPediatric Neurology, 2007
- PGC-1α protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcriptionProceedings of the National Academy of Sciences of the United States of America, 2006
- Changes in skeletal muscle SR Ca2+ pump in congestive heart failure due to myocardial infarction are prevented by angiotensin II blockadeCanadian Journal of Physiology and Pharmacology, 2004
- The Pore Region of the Skeletal Muscle Ryanodine Receptor Is a Primary Locus for Excitation-Contraction Uncoupling in Central Core DiseaseThe Journal of general physiology, 2003
- Post-translational disruption of dystroglycan–ligand interactions in congenital muscular dystrophiesNature, 2002
- Treatment of Normal Skeletal Muscle with FK506 or Rapamycin Results in Halothane-induced Muscle ContractureAnesthesiology, 1998
- Multiple Classes of Sulfhydryls Modulate the Skeletal Muscle Ca2+ Release ChannelOnline Journal of Public Health Informatics, 1997
- Exercise intolerance in patients with chronic heart failureProgress in Cardiovascular Diseases, 1995
- Regions of the skeletal muscle dihydropyridine receptor critical for excitation–contraction couplingNature, 1990
- Capacity of blood flow delivery to exercising skeletal muscle in humansThe American Journal of Cardiology, 1988