Intracerebral hemorrhage in a primate model: Effect on regional cerebral blood flow
- 29 February 1988
- journal article
- Published by Elsevier BV in Surgical Neurology
- Vol. 29 (2), 101-107
- https://doi.org/10.1016/0090-3019(88)90065-1
Abstract
The dynamic changes in regional cerebral blood flow (rCBF), induced by a developing intracerebral hematoma, were studied in eight anesthetized monkeys. Hematomas were generated by allowing femoral arterial blood to enter the caudate nucleus via a stereotactically implanted needle. Intracranial pressure peaked at 51 ± 8 mmHg at 3 minutes after the ictus, and remained high throughout the 3-hour procedure. Cerebral blood flow was significantly reduced in all brain regions for 1 hour after the ictus. The lowest rCBF values were recorded in the immediate clot penumbra and were below threshold levels for ischemic neuronal damage for 90 minutes after the hemorrhage.Keywords
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