HISTAMINE H2‐RECEPTORS IN THE BRAIN AND SLEEP PRODUCED BY CLONIDINE
Open Access
- 1 November 1977
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 61 (3), 441-443
- https://doi.org/10.1111/j.1476-5381.1977.tb08438.x
Abstract
Sleep was induced in chicks aged 4-7 days by intravenous injection of clonidine hydrochloride 0.04 μmol/kg. Sleep was not prevented or altered by a preceding intramuscular injection of blockers of histamine H2-receptors which were used in doses (as μmol/kg) of up to 800 (metiamide) and 2400 (cimetidine). Clonidine, therefore, does not cause sleep by stimulating H2-receptors in the brain. The highest dose of cimetidine used had a hypnotic action of its own.Keywords
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