The Medicines Advice Service Evaluation (MASE): a randomised controlled trial of a pharmacist-led telephone based intervention designed to improve medication adherence
Open Access
- 11 January 2016
- journal article
- research article
- Published by BMJ in BMJ Quality & Safety
- Vol. 25 (10), 759-769
- https://doi.org/10.1136/bmjqs-2015-004670
Abstract
Aim To test the effectiveness of a tailored, pharmacist-led centralised advice service to improve adherence to patients on established medications. Methods A parallel group randomised controlled trial was conducted. Patients prescribed at least one oral medication for type 2 diabetes and/or lipid regulation were eligible to participate. 677 patients of a mail-order pharmacy were recruited and randomised (340 intervention, 337 control). The intervention comprised two tailored telephone consultations with a pharmacist, 4–6 weeks apart, plus a written summary of the discussion and a medicines reminder chart. The primary outcome was self-reported adherence to medication at 6-month follow-up, collected via a postal questionnaire, analysed using generalised estimating equations. Secondary outcomes included prescription refill adherence, lipid and glycaemic control and patient satisfaction. Results In intention-to-treat analysis 36/340 (10.6%) of the intervention group were non-adherent (Conclusions A telephone intervention, led by a pharmacist and tailored to the individuals’ needs, can significantly improve medication adherence in patients with long-term conditions, using a mail-order pharmacy. Further work is needed to confirm a trend towards improved clinical outcome. Trial registration number NCT01864239.Keywords
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