A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals
- 1 January 2013
- journal article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 49 (26), 2715-2717
- https://doi.org/10.1039/c3cc00118k
Abstract
The first multicomponent catalytic asymmetric synthesis of spiroacetals has been described. Hybrid molecules comprising a spiroacetal scaffold (a natural-product inspired scaffold) and an α-amino acid motif (a privileged fragment) are easily available through a gold phosphate-catalysed one-pot three component coupling reaction of alkynols, anilines and glyoxylic acid.This publication has 28 references indexed in Scilit:
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