Heat shock protein 10 and signal transduction: a “capsula eburnea” of carcinogenesis?
- 1 January 2006
- journal article
- review article
- Published by Elsevier BV in Cell Stress and Chaperones
- Vol. 11 (4), 287-94
- https://doi.org/10.1379/csc-200.1
Abstract
To date, little is known either about the physical interactions of heat shock protein 10 (Hsp10) with other proteins within the cell or its involvement in signal transduction pathways. Hsp10 has been considered mainly as a partner of Hsp60 in the Hsp60/10 protein folding machine. Only recently, Hsp10 was reported to interact with proteins involved in deoxyribonucleic acid checkpoint inactivation, termination of M-phase, messenger ribonucleic acid export, import of nuclear proteins, nucleocytoplasmic transport, and pheromone signaling pathways. At the same time, Hsp10 expression can be up-regulated in cancer cells, because it accumulates as the cell transformation progresses. Recent data suggest that Hsp10 may be not only a component of the folding machine but also an active player of the cell signaling network, influencing cell cycle, nucleocytoplasmic transport, and metabolism, with putative roles in the lack of cell differentiation and in the inhibition of apoptosis. In this review, we revise the involvement of Hsp10 in signal transduction pathways and its possible role in cancer etiology.Keywords
This publication has 85 references indexed in Scilit:
- Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP‐ase pathwayThe FASEB Journal, 2004
- Hsp10 and Hsp60 Suppress Ubiquitination of Insulin-like Growth Factor-1 Receptor and Augment Insulin-like Growth Factor-1 Receptor Signaling in Cardiac MuscleJournal of Biological Chemistry, 2003
- Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoterHuman Genetics, 2003
- Molecular Chaperones—Cellular Machines for Protein FoldingAngewandte Chemie-International Edition, 2002
- Systematic variation in gene expression patterns in human cancer cell linesNature Genetics, 2000
- A Study of Early Pregnancy Factor Activity in the Sera of Women with Trophoblastic TumorAmerican Journal of Reproductive Immunology, 1999
- Early pregnancy factor in liver regeneration after partial hepatectomy in rats: Relationship with chaperonin 10Hepatology, 1994
- Structure of the human spermidine/spermine N1-acetyltransferase gene: Kxon/intron gene organization and localization to Xp22.1Biochemical and Biophysical Research Communications, 1992
- Effect of monoclonal antibodies to early pregnancy factor (EPF) on the in vivo growth of transplantable murine tumoursCancer Immunology, Immunotherapy, 1992
- Monoclonal antibodies to early pregnancy factor perturb tumour cell growthClinical and Experimental Immunology, 1990