The Impact of Transgenic Mosquitoes on Dengue Virulence to Humans and Mosquitoes
- 1 October 2009
- journal article
- research article
- Published by University of Chicago Press in The American Naturalist
- Vol. 174 (4), 565-577
- https://doi.org/10.1086/605403
Abstract
Dengue is a major public health concern in the tropics and subtropics. Innovative transgenic strategies to render Aedes aegypti mosquitoes, the primary vector of dengue, incompetent for dengue transmission are under development. We modeled the evolutionary impact of different transgenic mosquito strategies on dengue‐induced mortality, that is, dengue virulence, to both humans and mosquitoes. This model incorporates various evolutionary trade‐offs in dengue virus epidemiological traits, for example, a trade‐off between dengue transmission rate and its virulence to humans. Our results indicate that strategies that block transmission or reduce mosquito biting impose selection on dengue virulence in humans. This selection can be for either higher or lower virulence, depending on the interaction between the effect of the transgene and the trade‐offs in epidemiological traits, highlighting the need for detailed quantitative data to understand more fully the impact of mosquito transgenesis on dengue virulence. Dengue virulence in mosquitoes can be selected on by transgenic strategies of blocking transmission, decreased mosquito biting, increased mosquito background mortality, and increased mosquito infection‐induced mortality. Our results suggest that dengue control strategies that raise mosquito background mortality or mosquito infection‐induced mortality pose less risk of causing increased virulence to humans than strategies that block transmission or reduce mosquito biting.Keywords
This publication has 86 references indexed in Scilit:
- Spatial and Temporal Clustering of Dengue Virus Transmission in Thai VillagesPLoS Medicine, 2008
- Evolution of parasite virulence when host responses cause diseaseProceedings. Biological sciences, 2007
- Ecological and immunological determinants of dengue epidemicsProceedings of the National Academy of Sciences of the United States of America, 2006
- Engineering RNA interference-based resistance to dengue virus type 2 in genetically modified Aedes aegyptiProceedings of the National Academy of Sciences of the United States of America, 2006
- Persistent Emergence of DengueEmerging Infectious Diseases, 2005
- Ecological interference between fatal diseasesNature, 2003
- Dengue Viremia Titer, Antibody Response Pattern, and Virus Serotype Correlate with Disease SeverityThe Journal of Infectious Diseases, 2000
- Superinfection, Metapopulation Dynamics, and the Evolution of DiversityJournal of Theoretical Biology, 1994
- The Evolution of Virulence in Parasites and Pathogens: Reconciliation Between Two Competing HypothesesJournal of Theoretical Biology, 1994
- Evolutionary and continuous stabilityJournal of Theoretical Biology, 1983