Diagnosis of Parkinson's Disease Based on Disease-Specific Autoantibody Profiles in Human Sera
Open Access
- 22 February 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (2), e32383
- https://doi.org/10.1371/journal.pone.0032383
Abstract
Parkinson's disease (PD), hallmarked by a variety of motor disorders and neurological decline, is the second most common neurodegenerative disease worldwide. Currently, no diagnostic test exists to identify sufferers, and physicians must rely on a combination of subjective physical and neurological assessments to make a diagnosis. The discovery of definitive blood-borne biomarkers would be a major step towards early and reliable diagnosis. Despite attention devoted to this search, such biomarkers have remained elusive. In the present study, we used human protein microarrays to reveal serum autoantibodies that are differentially expressed among PD and control subjects. The diagnostic significance of each of these autoantibodies was evaluated, resulting in the selection of 10 autoantibody biomarkers that can effectively differentiate PD sera from control sera with a sensitivity of 93.1% and specificity of 100%. PD sera were also distinguishable from sera obtained from Alzheimer's disease, breast cancer, and multiple sclerosis patients with accuracies of 86.0%, 96.6%, and 100%, respectively. Results demonstrate that serum autoantibodies can be used as highly specific and accurate biomarkers for PD diagnosis throughout the course of the disease.Keywords
This publication has 27 references indexed in Scilit:
- Diagnosis of Alzheimer's Disease Based on Disease-Specific Autoantibody Profiles in Human SeraPLOS ONE, 2011
- Biomarker candidates of neurodegeneration in Parkinson’s disease for the evaluation of disease-modifying therapeuticsJournal of Neural Transmission, 2011
- α-Synuclein Reactive Antibodies as Diagnostic Biomarkers in Blood Sera of Parkinson's Disease PatientsPLOS ONE, 2011
- Neuroimaging in Parkinson's DiseaseNeurotherapeutics, 2011
- The Epidemiology of Dementia Associated with Parkinson's DiseaseBrain Pathology, 2010
- DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s diseaseBrain, 2010
- Cerebrospinal fluid α-synuclein in neurodegenerative disorders—A marker of synapse loss?Neuroscience Letters, 2009
- When does Parkinson's disease begin?Movement Disorders, 2009
- Parkinson's disease: clinical features and diagnosisJournal of Neurology, Neurosurgery & Psychiatry, 2008
- Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s diseaseBiochemical and Biophysical Research Communications, 2006