Myelodysplastic syndromes, aging, and age: Correlations, common mechanisms, and clinical implications
- 1 January 2007
- journal article
- review article
- Published by Informa UK Limited in Leukemia & Lymphoma
- Vol. 48 (10), 1900-1909
- https://doi.org/10.1080/10428190701534382
Abstract
Myelodysplastic syndromes (MDS) are a heterogenous group of myeloid neoplasms that develop primarily in elderly patients. Although a specific molecular basis for the predominant incidence of MDS in higher age groups remains unknown, several lines of evidence suggest that the biology of aging and the pathogenesis of MDS share several genetic, epigenetic, and molecular features. The current review attempts to delineate these common aspects as well as additional discriminative features that are specific for MDS and thus help explaining disease-evolution and progression. In addition, the present review discusses age as an important prognostic factor and co-variable to be considered in treatment algorithms in MDS.Keywords
This publication has 113 references indexed in Scilit:
- Epigenetic inactivation of the premature aging Werner syndrome gene in human cancerProceedings of the National Academy of Sciences, 2006
- Cytogenetic aspects of adult primary myelodysplastic syndromes: Clinical implicationsCancer Letters, 2006
- Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivoBlood, 2005
- Mitochondrial DNA spectra of single human CD34+ cells, T cells, B cells, and granulocytesBlood, 2005
- LPI-labile plasma iron in iron overloadBest Practice & Research Clinical Haematology, 2005
- IGF-1 signaling and agingExperimental Gerontology, 2004
- Epigenetics in human disease and prospects for epigenetic therapyNature, 2004
- Imbalance Between Apoptosis and Telomerase Activity in Myelodysplastic Syndromes: Possible Role in Ineffective HemopoiesisLeukemia & Lymphoma, 2003
- Differential occurrence of mutations in mitochondrial DNA of human skeletal muscle during agingHuman Mutation, 1998
- Bone remodeling alterations in myelodysplastic syndromeBone, 1996