Topical Ivermectin: A New Successful Treatment for Scabies
- 1 January 2001
- journal article
- clinical trial
- Published by Wiley in Pediatric Dermatology
- Vol. 18 (1), 63-65
- https://doi.org/10.1046/j.1525-1470.2001.018001063.x
Abstract
Ivermectin is the only one of the avermectins that has been widely used in humans, since it is recommended as the treatment of choice for onchocerciasis, a filariasis that produces “river blindness,” a parasitic endemic infestation in countries of West Equatorial Africa and in some areas of Central and South America. Also, ivermectin has been used for treating human endo- and ectoparasites with effective results and with almost no side effects. To study the efficacy of ivermectin for scabies, which is very common in Colombia, a trial with this drug that could be easily administered, with fast application and high efficacy, was undertaken. For this purpose, six complete families with active scabies, consisting of 12 adults and 20 children ranging in age from 1 to 10 years, were treated with 1% ivermectin in a solution of propylene glycol applied topically to the affected skin. The dose employed was 400 μg/kg, repeated once the following week. All patients were cured, tolerated the medication well, and there were no side effects or signs of recurrence 2, 4, or 6 weeks after therapy. In addition to its efficacy, easy administration, and lack of side effects, ivermectin is a low-cost medication.Keywords
This publication has 18 references indexed in Scilit:
- VERMECTIN‐RESPONSIVE CRUSTED SCABIES IN FOUR PATIENTSPediatric Dermatology, 1999
- A Risk-Benefit Assessment of Agents Used in the Treatment of ScabiesDrug Safety, 1996
- CUTANEOUS MYIASIS: REVIEW OF 13 CASES IN TRAVELERS RETURNING FROM TROPICAL COUNTRIESInternational Journal of Dermatology, 1995
- The Treatment of Scabies with IvermectinThe New England Journal of Medicine, 1995
- Efficacy of ivermectin in the therapy of larva currensArchives of Dermatology, 1994
- Environmental assessment of avermectins by the US food and drug administrationVeterinary Parasitology, 1993
- A field study of the effects of ivermectin on ectoparasites of manTransactions of the Royal Society of Tropical Medicine and Hygiene, 1991
- Efficacy of topically administered ivermectin against chorioptic and sarcoptic mange of cattleVeterinary Record, 1988
- Cutaneous OnchocerciasisInternational Journal of Dermatology, 1987
- Efficacy of ivermectin against Sarcoptes scabiei in pigsVeterinary Record, 1980