Extrahelical Damaged Base Recognition by DNA Glycosylase Enzymes
- 10 January 2008
- journal article
- review article
- Published by Wiley in Chemistry – A European Journal
- Vol. 14 (3), 786-793
- https://doi.org/10.1002/chem.200701501
Abstract
The efficient enzymatic detection of damaged bases concealed in the DNA double helix is an essential step during DNA repair in all cells. Emergent structural and mechanistic approaches have provided glimpses into this enigmatic molecular recognition event in several systems. A ubiquitous feature of these essential reactions is the binding of the damaged base in an extrahelical binding mode. The reaction pathway by which this remarkable extrahelical state is achieved is of great interest and even more debate.Keywords
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