Endoplasmic reticulum stress is implicated in retinal inflammation and diabetic retinopathy
Open Access
- 11 April 2009
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 583 (9), 1521-1527
- https://doi.org/10.1016/j.febslet.2009.04.007
Abstract
Diabetic retinopathy is a chronic low‐grade inflammatory disease; however, the mechanisms remain elusive. In the present study, we demonstrated that endoplasmic reticulum (ER) stress was activated in the retina in animal models of diabetes and oxygen‐induced retinopathy (OIR). Induction of ER stress by tunicamycin resulted in significantly increased expression of inflammatory molecules in the retina. Inhibition of ER stress by chemical chaperone 4‐phenyl butyric acid ameliorated inflammation in cultured human retinal endothelial cells exposed to hypoxia, and in the retinas of diabetic and OIR mice. These findings indicate that ER stress is a potential mediator of retinal inflammation in diabetic retinopathy.Keywords
This publication has 40 references indexed in Scilit:
- Antioxidants reduce endoplasmic reticulum stress and improve protein secretionProceedings of the National Academy of Sciences of the United States of America, 2008
- Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetesJCI Insight, 2008
- From endoplasmic-reticulum stress to the inflammatory responseNature, 2008
- Retinopathy of prematurityAngiogenesis, 2007
- Contributions of Inflammatory Processes to the Development of the Early Stages of Diabetic RetinopathyExperimental Diabetes Research, 2007
- Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 DiabetesScience, 2006
- Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipidsProceedings of the National Academy of Sciences of the United States of America, 2006
- Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetesDiabetologia, 2004
- Monocyte Chemotactic Protein-1 in the Vitreous of Patients with Proliferative Diabetic RetinopathyOphthalmologica, 2001
- Oxygen-induced retinopathy in the mouse.1994