The expression of the imprinted H19 and IGF‐2 genes in human bladder carcinoma
- 23 October 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 374 (1), 57-61
- https://doi.org/10.1016/0014-5793(95)01074-o
Abstract
The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.This publication has 24 references indexed in Scilit:
- Inherited microdeletions in the Angelman and Prader–Willi syndromes define an imprinting centre on human chromosome 15Nature Genetics, 1995
- Relaxation of Imprinting in Trophoblastic DiseaseGynecologic Oncology, 1994
- Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosinCell, 1993
- Tumour-suppressor activity of H19 RNANature, 1993
- Relaxation of imprinted genes in human cancerNature, 1993
- The expression of the H‐19 and IGF‐2 genes during human embryogenesis and placental developmentMolecular Reproduction and Development, 1993
- The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleusCell, 1992
- Physical linkage of two mammalian imprinted genes, H19 and insulin–like growth factor 2Nature Genetics, 1992
- Monoallelic expression of the human H19 geneNature Genetics, 1992
- ras GENESAnnual Review of Biochemistry, 1987