A case of hemophagocytic syndrome in a patient with fulminant ulcerative colitis superinfected by cytomegalovirus
Open Access
- 1 January 2013
- journal article
- case report
- Published by Korean Association of Internal Medicine in The Korean Journal of Internal Medicine
- Vol. 28 (3), 352-355
- https://doi.org/10.3904/kjim.2013.28.3.352
Abstract
Hemophagocytic syndrome (HPS) is an uncommon hematological disorder that manifests as fever, splenomegaly, and jaundice, with hemophagocytosis in the bone marrow and other tissues pathologically. Secondary HPS is associated with malignancy and infection, especially viral infection. The prevalence of cytomegalovirus (CMV) infection in ulcerative colitis (UC) patients is approximately 16%. Nevertheless, HPS in UC superinfected by CMV is very rare. A 52-year-old female visited the hospital complaining of abdominal pain and hematochezia for 6 days. She was diagnosed with UC 3 years earlier and had been treated with sulfasalazine, but had stopped her medication 4 months earlier. On admission, her spleen was enlarged. The peripheral blood count revealed pancytopenia and bone marrow aspiration smears showed hemophagocytosis. Viral studies revealed CMV infection. She was treated successfully with ganciclovir. We report this case with a review of the related literature.Keywords
This publication has 10 references indexed in Scilit:
- Cytomegalovirus Infection in Patients with Active Inflammatory Bowel DiseaseDigestive Diseases and Sciences, 2010
- Cytomegalovirus (CMV)Uirusu, 2010
- Hemophagocytic syndromesBlood Reviews, 2007
- Reactive hemophagocytic syndrome complicating the treatment of inflammatory bowel diseaseInflammatory Bowel Diseases, 2006
- Hemophagocytic Syndrome Caused by Fulminant Ulcerative Colitis and Cytomegalovirus Infection: Report of a CaseDiseases of the Colon & Rectum, 2004
- Prevalence of cytomegalovirus infection in severe refractory ulcerative and Crohn's colitisThe American Journal of Gastroenterology, 2001
- Hemophagocytic Syndromes and InfectionEmerging Infectious Diseases, 2000
- Interferon-gamma and tumor necrosis factor-alpha specifically induce formation of cytomegalovirus-permissive monocyte-derived macrophages that are refractory to the antiviral activity of these cytokines.JCI Insight, 1997
- Cytomegalovirus infection masquerading as an ulcerative colitis flare-up: case report and review of the literature.1996
- Virus-associated hemophagocytic syndromeA benign histiocytic proliferation distinct from malignant histiocytosisCancer, 1979