Modern Aldol Methods for the Total Synthesis of Polyketides
Top Cited Papers
- 14 November 2006
- journal article
- review article
- Published by Wiley in Angewandte Chemie-International Edition
- Vol. 45 (45), 7506-7525
- https://doi.org/10.1002/anie.200602780
Abstract
The aldol reaction is one of the most important methods for the stereoselective construction of polyketide natural products, not only for nature but also for synthetic chemistry. The tremendous development in the field of aldol additions during the last 30 years has led to more and more total syntheses of complicated natural products. This Review illustrates by means of selected syntheses of natural products the new variants of the aldol addition. This includes aldol additions with various metal enolates, as well as metal‐complex‐catalyzed, organocatalytic, and biocatalytic methods.This publication has 187 references indexed in Scilit:
- The Total Synthesis of (−)‐Callystatin AChemistry – A European Journal, 2003
- A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone BAngewandte Chemie-International Edition, 1998
- Eine neuartige Aldolkondensation mit 2-Methyl-4-pentenal und ihr Einsatz in einer verbesserten Totalsynthese von Epothilon BAngewandte Chemie, 1998
- Totalsynthese von Altohyrtin A (Spongistatin 1): Teil 2Angewandte Chemie, 1998
- Totalsynthese von Altohyrtin A (Spongistatin 1): Teil 1Angewandte Chemie, 1998
- Enantioselective Synthesis of Altohyrtin C (Spongistatin 2): Fragment Assembly and Revision of the Spongistatin 2 Stereochemical AssignmentAngewandte Chemie-International Edition, 1997
- Enantioselective Synthesis of Altohyrtin C (Spongistatin 2): Synthesis of the EF‐Bis(pyran) SubunitAngewandte Chemie-International Edition, 1997
- Enantioselective Synthesis of Altohyrtin C (Spongistatin 2): Synthesis of the AB‐ and CD‐Spiroketal SubunitsAngewandte Chemie-International Edition, 1997
- Enantioselective Aldol Reaction of tert‐Butyl Acetate using Titanium‐Carbohydrate ComplexesAngewandte Chemie-International Edition, 1989
- Makrolide. Neuere Fortschritte ihrer Chemie und BiochemieAngewandte Chemie, 1977