Rhabdoid glioblastoma in a child: case report and literature review
- 7 January 2011
- journal article
- case report
- Published by Springer Science and Business Media LLC in Brain Tumor Pathology
- Vol. 28 (1), 65-70
- https://doi.org/10.1007/s10014-010-0010-4
Abstract
Rhabdoid glioblastoma is a rare type of glioblastoma characterized by cells resembling rhabdomyoblasts. Several reports have identified its aggressive clinical course and the pathological differences from other primary brain tumors. We report a case of rhabdoid glioblastoma in a 12-year-old boy who presented with headache and harbored a 70-mm solid tumor in the left temporal lobe. The tumor was surgically excised, but early tumor recurrence and leptomeningeal spread developed, and the patient died of the disease 4.9 months after surgery. Histologically, the tumor contained two distinct patterns of glioblastoma and rhabdoid cells with necrosis and hemorrhage. Immunohistochemical analysis revealed that both cells were positive for glial fibrillary acid protein, vimentin, and INI1, which is consistent with the reported diagnosis of rhabdoid glioblastoma. Genetic studies confirmed no loss of the INI1 gene and identified hemizygous deletion of the CDKN2A gene. We review reported cases of rhabdoid glioblastoma and summarize the clinical, radiological, and histological features.Keywords
This publication has 15 references indexed in Scilit:
- Benefits of interferon‐β and temozolomide combination therapy for newly diagnosed primary glioblastoma with the unmethylated MGMT promoterCancer, 2010
- Epithelioid Versus Rhabdoid Glioblastomas Are Distinguished by Monosomy 22 and Immunohistochemical Expression of INI-1 but not Claudin 6The American Journal of Surgical Pathology, 2010
- Mouse models of CNS embryonal tumorsBrain Tumor Pathology, 2009
- Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomasActa Neuropathologica, 2009
- Epithelial and pseudoepithelial differentiation in glioblastoma and gliosarcomaCancer, 2008
- Advantage of FISH analysis using FKHR probes for an adjunct to diagnosis of rhabdomyosarcomasVirchows Archiv, 2007
- Characterization of Glioblastomas in Young AdultsBrain Pathology, 2006
- INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomasLaboratory Investigation, 2005
- Malignant rhabdoid meningioma arising in the setting of preexisting ganglioglioma: a diagnosis supported by fluorescence in situ hybridizationJournal of Neurosurgery, 2002
- The Lipid-Rich Epithelioid GlioblastornaThe American Journal of Surgical Pathology, 1991