Ultrastructural Findings in Bullous Pemphigoid
- 1 August 1975
- journal article
- Published by Wiley in Journal of Cutaneous Pathology
- Vol. 2 (2), 103-108
- https://doi.org/10.1111/j.1600-0560.1975.tb00214.x
Abstract
In four bullous pemphigoid patients electron microscopic and direct immunofluorescence examinations were carried out on sections of the border of a blister, apparently normal skin surrounding the blister, apparently normal skin distant from the blister, and apparently normal skin subjected to the stimulus of a xenon lamp. The bullous pemphigoid blister was formed by cleavage of the basal cells away from the basal lamina which remained intact. The intercellular spaces were widened and the half-desmosomes reduced in number in the skin surrounding the blister. Xenon lamp irradiation produced a pattern similar to that of the skin surrounding the blister, but without immunoglobulins and complement fixed in vivo.Keywords
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