Coronary Thermodilution to Assess Flow Reserve
- 23 October 2001
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation
- Vol. 104 (17), 2003-2006
- https://doi.org/10.1161/hc4201.099223
Abstract
Background Fractional flow reserve (FFR) and coronary flow reserve (CFR) are indices of coronary stenosis severity that provide the clinician with complementary information on the contribution of epicardial arteries and microcirculation to total resistance to myocardial blood flow. At present, FFR and CFR can only be obtained by 2 separate guidewires. The present study tested the validity of the thermodilution principle in assessing CFR with one pressure-temperature sensor-tipped guidewire. Methods and Results In an in vitro model, absolute flow was compared with the inverse mean transit time (1/T mn ) of a thermodilution curve obtained after a bolus injection of 3 mL of saline at room temperature. A very close correlation ( r >0.95) was found between absolute flow and 1/T mn when the sensor was placed ≥6 cm from the injection site. In 6 chronically instrumented dogs (60 stenoses; FFR from 0.19 to 0.98), a significant linear relation was found between flow velocity and 1/T mn . A significant correlation was found between CFR Doppler , which was calculated from the ratio of hyperemic to resting flow velocities, and CFR thermo , which was calculated from the ratio of resting to hyperemic T mn ( r =0.76; SEE=0.24; P Conclusion The present findings demonstrate the validity of the thermodilution principle to assess CFR. Because the pressure-temperature sensor was mounted in a commercially available angioplasty guidewire, this technique permits simultaneous measurements of CFR and FFR.This publication has 5 references indexed in Scilit:
- Practical Set-Up of Coronary Pressure MeasurementDevelopments in Cardiovascular Medicine, 2000
- Clinical outcome of deferring angioplasty in patients with normal translesional pressure-flow velocity measurementsJournal of the American College of Cardiology, 1995
- Physiologic basis for assessing critical coronary stenosis: Instantaneous flow response and regional distribution during coronary hyperemia as measures of coronary flow reserveThe American Journal of Cardiology, 1974
- A new technique for measurement of cardiac output by thermodilution in manThe American Journal of Cardiology, 1971
- On the Theory of the Indicator-Dilution Method for Measurement of Blood Flow and VolumeJournal of Applied Physiology, 1954