Nondigestible oligosaccharides do not interfere with calcium and nonheme-iron absorption in young, healthy men
Open Access
- 1 March 1998
- journal article
- clinical trial
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 67 (3), 445-451
- https://doi.org/10.1093/ajcn/67.3.445
Abstract
The effect of inulin, fructooligosaccharides, and galactooligosaccharides on true intestinal absorption of iron and calcium was measured in men by using double stable-isotope techniques (oral 57Fe and 44Ca and intravenous 58Fe and 48Ca). The incorporation of iron isotopes into erythrocytes and the urinary excretion of calcium isotopes was measured with an inductively coupled plasma mass spectrometer. Twelve healthy, nonanemic, male subjects aged 20-30 y received four treatments consisting of a constant basal diet supplemented with 15 g/d inulin, fructooligosaccharide, or galactooligosaccharide, or not supplemented (control treatment). These four treatments were given for 21 d each according to a randomized, crossover design. Iron absorption was measured over the last 7 d of treatment (days 15-21) and calcium absorption was measured on day 21 of each treatment period. Mean (+/- SEM) iron absorption was 5.5 +/- 1.6%, 6.1 +/- 1.9%, 5.3 +/- 1.9%, and 5.1 +/- 1.5%, respectively, during treatment with inulin, fructooligosaccharide, galactooligosaccharide, or the control; mean ( SEM) calcium absorption was 25.8 +/- 2.3%, 26.3 +/- 1.9%, 26.3 +/- 2.6%, and 28.1 +/- 4.3%, respectively. None of the differences between treatments was significant. It is concluded that 15 g/d inulin, fructooligosaccharide, or galactooligosaccharide did not have a negative effect on iron and calcium absorption in young healthy men.Keywords
This publication has 21 references indexed in Scilit:
- Results of Surveys to Assess Iron Status in EuropePublished by Oxford University Press (OUP) ,2009
- Overview and Mechanisms of Iron RegulationNutrition Reviews, 2009
- Effect of fermentable fructo-oligosaccharides on mineral, nitrogen and energy digestive balance in the ratLife Sciences, 1995
- Effects of Fructooligosaccharides on the Absorption of Iron, Calcium and Magnesium in Iron-deficient Anemic Rats.Journal of Nutritional Science and Vitaminology, 1995
- A double stable isotope technique for measuring iron absorption in infantsBritish Journal of Nutrition, 1994
- Effects of Dietary Fibre Mixtures on Glucose and Lipid Metabolism and on Mineral Absorption in the RatAnnals of Nutrition and Metabolism, 1994
- Table of the isotopic compositions of the elementsInternational Journal of Mass Spectrometry and Ion Processes, 1993
- Serum transferrin receptor as an index of iron absorptionBritish Journal of Haematology, 1990
- Studies on calcium absorption from milk using a double-label stable isotope techniqueBritish Journal of Nutrition, 1989
- One-day test using stable isotopes to measure true fractional calcium absorptionJournal of Bone and Mineral Research, 1989