Bioactive ent-Kaurene Diterpenoids from Annona senegalensis
- 1 January 1996
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 59 (3), 301-303
- https://doi.org/10.1021/np9601566
Abstract
Activity-guided fractionation of the stem bark of Annona senegalensis gave four bioactive ent-kaurenoids (1−4). Compound 2 showed selective and significant cytotoxicity for MCF-7 (breast cancer) cells (ED50 1.0 μg/mL), and 3 and 4 exhibited cytotoxic selectivity for PC-3 (prostate cancer) cells but with weaker potencies (ED50 17−18 μg/mL). The structure of the new compound, 3, was deduced from spectral evidence.Keywords
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