Sub-10 nm Fe3O4@Cu2–xS Core–Shell Nanoparticles for Dual-Modal Imaging and Photothermal Therapy
Top Cited Papers
- 20 May 2013
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 135 (23), 8571-8577
- https://doi.org/10.1021/ja4013497
Abstract
Photothermal nanomaterials have recently attracted significant research interest due to their potential applications in biological imaging and therapeutics. However, the development of small-sized photothermal nanomaterials with high thermal stability remains a formidable challenge. Here, we report the rational design and synthesis of ultrasmall (3O4@Cu2–xS core–shell nanoparticles, which offer both high photothermal stability and superparamagnetic properties. Specifically, these core–shell nanoparticles have proven effective as probes for T2-weighted magnetic resonance imaging and infrared thermal imaging because of their strong absorption at the near-infrared region centered around 960 nm. Importantly, the photothermal effect of the nanoparticles can be precisely controlled by varying the Cu content in the core–shell structure. Furthermore, we demonstrate in vitro and in vivo photothermal ablation of cancer cells using these multifunctional nanoparticles. The results should provide improved understanding of synergistic effect resulting from the integration of magnetism with photothermal phenomenon, important for developing multimode nanoparticle probes for biomedical applications.This publication has 52 references indexed in Scilit:
- Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancerBiomaterials, 2011
- Tuning upconversion through energy migration in core–shell nanoparticlesNature Materials, 2011
- Monodisperse Magnetic Nanoparticles for Theranostic ApplicationsAccounts of Chemical Research, 2011
- Copper Selenide Nanocrystals for Photothermal TherapyNano Letters, 2011
- Gold Nanocages: From Synthesis to Theranostic ApplicationsAccounts of Chemical Research, 2011
- Photothermally Enhanced Drug Delivery by Ultrasmall Multifunctional FeCo/Graphitic Shell NanocrystalsACS Nano, 2011
- A Chelator-Free Multifunctional [64Cu]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation TherapyJournal of the American Chemical Society, 2010
- Multifunctional nanoparticles as coupled contrast agentsNature Communications, 2010
- Bifunctional Gold Nanoshells with a Superparamagnetic Iron Oxide−Silica Core Suitable for Both MR Imaging and Photothermal TherapyThe Journal of Physical Chemistry C, 2007
- Microscale Heat Transfer Transduced by Surface Plasmon Resonant Gold NanoparticlesThe Journal of Physical Chemistry C, 2007