Mechanoelectric feedback in cardiac cells
- 15 June 2001
- journal article
- Published by The Royal Society in Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
- Vol. 359 (1783), 1173-1185
- https://doi.org/10.1098/rsta.2001.0824
Abstract
Cardiac electrophysiology is affected by cardiac mechanics. The input from the heart's mechanical environment to its electrical behaviour has been termed mechanoelectric feedback (MEF) and is well documented by more than a century of clinical observations on mechanical modulation of heart rate and rhythm. The mechanisms underlying cardiac MEF have been investigated for only a few decades and include stretch activation of ion channels and mechanical modulation of cellular Ca2+ handling. This review briefly outlines the scope and limitations of current experimental insight and its implementation in mathematical models of cardiac cellular activity.Keywords
This publication has 48 references indexed in Scilit:
- Tarantula peptide inhibits atrial fibrillationNature, 2001
- TREK-2, a New Member of the Mechanosensitive Tandem-pore K+ Channel FamilyJournal of Biological Chemistry, 2000
- [24] Mechanosensitive channels of bacteriaMethods in enzymology, 1999
- Stretch-Induced Alkalinization of Feline Papillary MuscleCirculation Research, 1998
- Electrophysiological effects of myocardial stretch and mechanical determinants of stretch-activated arrhythmias.Circulation, 1992
- Myocardial stretch alters twitch characteristics and Ca2+ loading of sarcoplasmic reticulum in rat ventricular muscleCardiovascular Research, 1992
- The cellular basis of the length-tension relation in cardiac muscleJournal of Molecular and Cellular Cardiology, 1985
- The effects of muscle length on intracellular calcium transients in mammalian cardiac muscle.The Journal of Physiology, 1982
- Effect of stretch on conduction velocity and cable properties of cardiac Purkinje fibersAmerican Journal of Physiology-Cell Physiology, 1979
- Dependence of the contractile activation of skinned cardiac cells on the sarcomere lengthNature, 1975