Differences in immune response may explain lower survival among older men with pneumonia*
- 1 May 2009
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Critical Care Medicine
- Vol. 37 (5), 1655-1662
- https://doi.org/10.1097/ccm.0b013e31819da853
Abstract
Lower life expectancy in men is generally attributed to higher likelihood of risky behavior and because men develop chronic conditions earlier. If sex-related differences in survival are independent of preinfection chronic health and health behavior, it would suggest that survival differences may occur because of sex differences in quality of care and biological response to infection, and these differences may contribute to sex differences in life expectancy. We assessed if sex-related survival difference following community-acquired pneumonia (CAP) is due to differences in clinical characteristics, quality of care, or immune response. Prospective observational cohort of 2183 subjects with CAP. Mean age was 64.9 years. Men were more likely to smoke and had more comorbidity compared with women. At emergency department presentation, men had different biomarker patterns, as evidenced by higher inflammation (tumor necrosis factor, interleukin [IL]-6, and IL-10) and fibrinolysis (d-dimer), and lower coagulation biomarkers (antithrombin-III and factor IX) (p p Lower survival among men following CAP was not explained by differences in chronic diseases, health behaviors, and quality of care. Patterns of inflammatory, coagulation, and fibrinolysis biomarkers among men may explain reduced short-term and long-term survival.This publication has 32 references indexed in Scilit:
- Estradiol is associated with mortality in critically ill trauma and surgical patientsCritical Care Medicine, 2008
- Gender dimorphism following injury: making the connection from bench to bedsideJournal of Leukocyte Biology, 2007
- Understanding the Inflammatory Cytokine Response in Pneumonia and SepsisArchives of Internal Medicine, 2007
- Comparison of Cox and Gray’s survival models in severe sepsis*Critical Care Medicine, 2004
- Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]Critical Care, 2004
- Gender-dependent differences in outcome after the treatment of infection in hospitalized patients.JAMA, 1999
- Test of the National Death Index and Equifax Nationwide Death SearchAmerican Journal of Epidemiology, 1994
- Serum Cytokine Levels in Human Septic ShockSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1993
- The APACHE III Prognostic SystemSocial psychiatry. Sozialpsychiatrie. Psychiatrie sociale, 1991
- A new method of classifying prognostic comorbidity in longitudinal studies: Development and validationJournal of Chronic Diseases, 1987