Transition‐Metal‐Catalyzed Enantioselective [2+2+2] Cycloadditions for the Synthesis of Axially Chiral Biaryls
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- 30 March 2009
- journal article
- review article
- Published by Wiley in Chemistry – An Asian Journal
- Vol. 4 (4), 508-518
- https://doi.org/10.1002/asia.200800378
Abstract
Tying up loose ends: Recent advances towards a development of novel transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of biaryls are summarized in this Focus Review. Additionally, the enantioselective synthesis of axially chiral biaryls possessing non-biaryl axial chirality is also presented. These novel asymmetric aromatization reactions allow the production of various axially chiral biaryl compounds with high enantioselectivity. Recent advances towards a development of novel transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of axially chiral biaryls are reviewed. A number of efficient enantioselective biaryl syntheses were accomplished by chiral cobalt(I), iridium(I), and rhodium(I) complex catalyzed [2+2+2] cycloadditions. Furthermore, the enantioselective synthesis of axially chiral biaryls possessing non-biaryl axial chirality was also developed by using chiral rhodium(I) complexes as catalysts.Keywords
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