Induction and Suppression of RNA Silencing by an Animal Virus
Top Cited Papers
- 17 May 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 296 (5571), 1319-1321
- https://doi.org/10.1126/science.1070948
Abstract
RNA silencing is a sequence-specific RNA degradation mechanism that is operational in plants and animals. Here, we show that flock house virus (FHV) is both an initiator and a target of RNA silencing in Drosophila host cells and that FHV infection requires suppression of RNA silencing by an FHV-encoded protein, B2. These findings establish RNA silencing as an adaptive antiviral defense in animal cells. B2 also inhibits RNA silencing in transgenic plants, providing evidence for a conserved RNA silencing pathway in the plant and animal kingdoms.Keywords
This publication has 18 references indexed in Scilit:
- A viral protein inhibits the long range signaling activity of the gene silencing signalThe EMBO Journal, 2002
- RNA silencingCurrent Biology, 2002
- An Effective AIDS Vaccine Based on Live Attenuated Vesicular Stomatitis Virus RecombinantsCell, 2001
- Argonaute2, a Link Between Genetic and Biochemical Analyses of RNAiScience, 2001
- RNA Silencing in Plants--Defense and CounterdefenseScience, 2001
- Systemic spread of an RNA insect virus in plants expressing plant viral movement protein genesProceedings of the National Academy of Sciences, 2001
- A Species of Small Antisense RNA in Posttranscriptional Gene Silencing in PlantsScience, 1999
- Strong host resistance targeted against a viral suppressor of the plant gene silencing defence mechanismThe EMBO Journal, 1999
- Viral pathogenicity determinants are suppressors of transgene silencing in Nicotiana benthamianaThe EMBO Journal, 1998
- An interspecies hybrid RNA virus is significantly more virulent than either parental virus.Proceedings of the National Academy of Sciences, 1996