Retrotransposon-induced mosaicism in the neural genome
Open Access
- 18 July 2018
- journal article
- review article
- Published by The Royal Society in Open Biology
- Vol. 8 (7)
- https://doi.org/10.1098/rsob.180074
Abstract
Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life. In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain. Retrotransposition in the developing brain, as well as during adult neurogenesis, provides a milieu in which neural diversity can arise. Dysregulation of retrotransposon activity may also contribute to neurological disease. Here, we review recent reports of retrotransposon activity in the brain, and discuss the temporal nature of retrotransposition and its regulation in neural cells in response to stimuli. We also put forward hypotheses regarding the significance of retrotransposons for brain development and neurological function, and consider the potential implications of this phenomenon for neuropsychiatric and neurodegenerative conditions.Keywords
Funding Information
- NHMRC-ARC Research Fellowship (GNT1108258)
- CSL Centenary Fellowship
This publication has 228 references indexed in Scilit:
- Single-Neuron Sequencing Analysis of L1 Retrotransposition and Somatic Mutation in the Human BrainCell, 2012
- TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathiesTrends in Molecular Medicine, 2011
- Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosisAnnals of Neurology, 2010
- Human endogenous retroviruses and multiple sclerosis: Innocent bystanders or disease determinants?Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2010
- LINE-1 Retrotransposition Activity in Human GenomesCell, 2010
- Natural Mutagenesis of Human Genomes by Endogenous RetrotransposonsCell, 2010
- LINE-1 retrotransposons: mediators of somatic variation in neuronal genomes?Trends in Neurosciences, 2010
- SVA retrotransposons: Evolution and genetic instabilitySeminars in Cancer Biology, 2010
- Environmental influence on L1 retrotransposons in the adult hippocampusHippocampus, 2009
- Purification, sequence, and cellular localization of a novel chromosomal protein that binds to Methylated DNACell, 1992