Thyroid Hormone and Wound Healing
Open Access
- 20 March 2013
- journal article
- review article
- Published by Hindawi Limited in Journal of Thyroid Research
- Vol. 2013, 1-5
- https://doi.org/10.1155/2013/124538
Abstract
Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3 has accelerated wound healing and hair growth in rodents. Topical T4 has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature regarding thyroid hormone action on skin along with skin manifestations of thyroid disease. The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cells in vitro and in vivo which may portend the use of thyroid hormone to promote wound healing. Although thyroid hormone is one of the most potent stimulators of growth and metabolic rate, the potential to use thyroid hormone to treat cutaneous pathology has never been subject to rigorous investigation. A number of investigators have demonstrated intriguing therapeutic potential for topical thyroid hormone. Topical T3 has accelerated wound healing and hair growth in rodents. Topical T4 has been used to treat xerosis in humans. It is clear that the use of thyroid hormone to treat cutaneous pathology may be of large consequence and merits further study. This is a review of the literature regarding thyroid hormone action on skin along with skin manifestations of thyroid disease. The paper is intended to provide a context for recent findings of direct thyroid hormone action on cutaneous cells in vitro and in vivo which may portend the use of thyroid hormone to promote wound healing.Keywords
This publication has 70 references indexed in Scilit:
- The Thyroid Hormone Receptors Modulate the Skin Response to RetinoidsPLOS ONE, 2011
- The Thyroid Hormone Receptors as Modulators of Skin Proliferation and InflammationPublished by Elsevier BV ,2011
- Exploring the “Thyroid–Skin Connection”: Concepts, Questions, and Clinical RelevanceJournal of Investigative Dermatology, 2010
- Deiodinases: implications of the local control of thyroid hormone actionJCI Insight, 2006
- Expression of Hypothalamic–Pituitary–Thyroid Axis RelatedGenes in the Human SkinJournal of Investigative Dermatology, 2002
- Type II and type III monodeiodinase activities in the skin of untreated and propylthiouracil-treated cashmere goatsResearch in Veterinary Science, 2000
- Effects of 3,5,3'‐triiodothyronine on collagen synthesis by cultured human skin fibroblastsFEBS Letters, 1984
- Thyrotoxicosis in Ethiopian patients—a prospective studyTransactions of the Royal Society of Tropical Medicine and Hygiene, 1982
- Mechanisms of Edema Formation in Myxedema — Increased Protein Extravasation and Relatively Slow Lymphatic DrainageNew England Journal of Medicine, 1979
- PERIPHERAL EFFECTS OF l-THYROXINE ON HAIR GROWTH AND COLORATION IN CATTLEJournal of Endocrinology, 1960