HLA-B Locus in Japanese Patients with Anti-Epileptics and Allopurinol-Related Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
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- 20 November 2008
- journal article
- research article
- Published by Informa UK Limited in Pharmacogenomics
- Vol. 9 (11), 1617-1622
- https://doi.org/10.2217/14622416.9.11.1617
Abstract
Introduction: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong associations of HLA-B*1502 and HLA-B*5801 with carbamazepine- and allopurinol-induced severe cutaneous adverse reactions were found in Han Chinese patients, respectively, but ethnic differences in the associations have been reported. The objective of this study is to clarify the involvement of HLA-B*1502 and HLA-B*5801 in Japanese SJS/TEN patients. Methods: HLA-B genotyping was performed on 58 Japanese SJS/TEN patients between July 2006 and April 2008 from multicenters in Japan. Results: There were no HLA-B*1502 carriers among 58 SJS/TEN patients. This patient group included seven carbamazepine-related and 11 aromatic anti-epileptic agent-related SJS/TEN patients. In addition, there were five HLA-B*5801 carriers, which included four allopurinol-related SJS/TEN patients. Conclusion: While HLA-B*1502 is unlikely to be associated with carbamazepi...Keywords
Funding Information
- Health and Labor Sciences Research Grant (Research on Advanced Medical Technology) from the Ministry of Health, Labor and Welfare
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