Susceptibility of zygomycetes to human serum
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 19 (2), 111-115
- https://doi.org/10.1080/00362178185380171
Abstract
Seven members of the class Zygomycetes were tested for serum susceptibility. Five of the isolates were inhibited to different degrees by pooled fresh human serum. Heating the serum at 56°C for 30min to inactivate complement did not abolish the inhibitory activity in the serum. Members of the genera Cunninghamella and Absidia appeared most susceptable to the inhibitory effects of serum while members of the genus Rhizopus were most resistant. One isolate of R. arrhizus appeared to have enhanced growth in the presence of human serum. Our findings suggest certain species of the class Zygomycetes are strongly inhibited by serum, and this may account for the rarity of human infections by these species. Sieben Stämme der Klasse Zygomyzeten wurden auf Serum-Empfindlichkeit geprüft. Fünf der Isolate wurden unterschiedlich stark gehemmt durch gepooltes frisches Humanserum. Trotz Erhitzen des Serums auf 56°C während 30 Minuten (Komplement-Inaktivierung) blieb die hemmende Wirkung des Serums erhalten. Stämme der Genera Cunninghamella und Absidia waren höchst empfindlich gegenüber dem hemmenden Effekt des Serums, währenddem sich der Genus Rhizopus höchst resistent zeigte. Ein Isolat von R. arrhizus wuchs sogar besser in Anwesenheit des Serums. Unsere Befunde zeigen, dass gewisse Spezies der Zygomyzeten stark durch das Serum gehemmt werden. Dies mag der Grund sein, warum die Zygomyzeten-Infektionen beim Menschen selten sind.This publication has 18 references indexed in Scilit:
- Rhinocerebral mucormycosis: premortem diagnosis and therapyArchives of Internal Medicine, 1979
- Mucormycotic slough of nasal floor and palate in the anephric patientThe Journal of the American Dental Association, 1979
- Rhizopus osteomyelitisAmerican Journal Of Medicine, 1979
- A Hemolytic Plate Method for Alternative-pathway Complement Activity AssayAmerican Journal of Clinical Pathology, 1978
- Pulmonary phycomycosis without obvious predisposing factorsJAMA, 1976
- Pulmonary MucormycosisNew England Journal of Medicine, 1972
- Alternate-Day Amphotericin B Therapy in the Treatment of Rhinocerebral Phycomycosis (Mucormycosis)Annals of Internal Medicine, 1968
- Rhino-Orbital MucormycosisAmerican Journal of Ophthalmology, 1967
- STUDIES OF OPPORTUNISTIC FUNGIThe American Journal of the Medical Sciences, 1961
- LEUKOPENIA WITH GRANULOCYTOPENIA IN EXPERIMENTAL MUCORMYCOSIS (RHIZOPUS ORYZAE INFECTIONThe Journal of Experimental Medicine, 1957