Association of Immunologic and Virologic Factors With Myocardial Infarction Rates in a US Healthcare System
- 15 December 2010
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in JAIDS Journal of Acquired Immune Deficiency Syndromes
- Vol. 55 (5), 615-619
- https://doi.org/10.1097/qai.0b013e3181f4b752
Abstract
Background: The effects of immunologic and virologic factors on acute myocardial infarction (AMI) rates in patients with HIV are unclear. Methods: HIV-infected patients in a US healthcare system were assessed for AMI. Results: Of 6517 patients with HIV, 273 (4.2%) had an AMI. In a model adjusting for cardiovascular risk factors, antiretroviral medications, and HIV parameters, CD4 count less than 200/mm3 (odds ratio, 1.74; 95% confidence interval, 1.07 to 2.81; P = 0.02) predicted AMI. Increased HIV viral load was associated with AMI accounting for cardiovascular disease risk factors and antiretroviral medications but was not significant when CD4 count was considered. Conclusions: Immunologic control appears to be the most important HIV-related factor associated with AMI.Keywords
This publication has 15 references indexed in Scilit:
- Traditional risk factors and D-dimer predict incident cardiovascular disease events in chronic HIV infectionAIDS, 2010
- Risk of Myocardial Infarction in Patients with HIV Infection Exposed to Specific Individual Antiretroviral Drugs from the 3 Major Drug Classes: The Data Collection on Adverse Events of Anti‐HIV Drugs (D:A:D) StudyThe Journal of Infectious Diseases, 2010
- Kidney function and the risk of cardiovascular events in HIV-1-infected patientsAIDS, 2010
- Non-AIDS-defining deaths and immunodeficiency in the era of combination antiretroviral therapyAIDS, 2009
- Association of C-Reactive Protein and HIV Infection With Acute Myocardial InfarctionJAIDS Journal of Acquired Immune Deficiency Syndromes, 2009
- Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patientsAIDS, 2008
- Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and menAIDS, 2008
- CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infectionAIDS, 2008
- Increased Acute Myocardial Infarction Rates and Cardiovascular Risk Factors among Patients with Human Immunodeficiency Virus DiseaseJournal of Clinical Endocrinology & Metabolism, 2007
- Class of Antiretroviral Drugs and the Risk of Myocardial InfarctionThe New England Journal of Medicine, 2007