Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives
Open Access
- 1 January 2015
- journal article
- review article
- Published by Hindawi Limited in Disease Markers
- Vol. 2015, 1-8
- https://doi.org/10.1155/2015/520590
Abstract
Lung cancer is one of the most common types of human malignancies and the leading cause of cancer-related death. Patients with surgically resectable early stage lung cancer are more likely curable, but currently only a small population of patients can be diagnosed at such a stage, partly due to our incomplete understanding of the biology of lung cancer and the lack of diagnostic and prognostic biomarkers. Recent studies have shown that NOTCH1 is a critical regulator of human carcinogenesis and has been implicated in multiple steps of cancer development and progression. Herein, we review recent findings about the role of NOTCH1 in lung cancer and discuss its potential usefulness as both a therapeutic target and a biomarker for lung cancer.Keywords
Funding Information
- National Institutes of Health (CA 190272 RELIEF)
This publication has 47 references indexed in Scilit:
- Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent mannerMolecular Cancer, 2015
- Notch1 signaling controls cell proliferation, apoptosis and differentiation in lung carcinomaLung Cancer, 2014
- From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch SignalingCancer Cell, 2014
- Notch1 Is Required for Kras-Induced Lung Adenocarcinoma and Controls Tumor Cell Survival via p53Cancer Research, 2013
- Potential Therapeutic Role of Z-Isochaihulactone in Lung Cancer through Induction of Apoptosis via Notch SignalingEvidence-Based Complementary and Alternative Medicine, 2012
- Cross-talk between endothelial cells and tumor via delta-like ligand4/Notch/PTEN signaling inhibits lung cancer growthOncogene, 2011
- Alterations of the Notch pathway in lung cancerProceedings of the National Academy of Sciences of the United States of America, 2009
- [Expression and significance of Notch1, Jagged1 and VEGF in human non-small cell lung cancer].2007
- Notch Signaling PathwayScience's STKE, 2006
- Notch signaling is an important regulator of type 2 immunityThe Journal of Experimental Medicine, 2005