Phorbol Ester Receptors: Autoradiographic Identification in the Developing Rat
- 2 December 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 222 (4627), 1036-1038
- https://doi.org/10.1126/science.6316499
Abstract
Autoradiography with 3H-labeled phorbol dibutyrate was used for the light microscopic detection of phorbol ester receptors in rat fetuses. In 15- and 18-day fetuses, as well as in adult rats, receptors were found to be concentrated in the central nervous system. The localization of receptors in the ventral marginal zone of the fetal neural tube, the lens of the eye, and other sites suggests a role for phorbol ester receptors in cellular process extension and cell-cell interaction.Keywords
This publication has 11 references indexed in Scilit:
- Regional localization ny light microscopic autoradiography of receptors in mouse brain for phorbol ester tumor promotersCancer Letters, 1983
- Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membraneNature, 1983
- Phosphatidylinositol specific phospholipases CLife Sciences, 1982
- Is phosphatidylinositol now out of the calcium gate?Nature, 1982
- Phorbol ester tumor promoters induce epidermal transglutaminase activityBiochemical and Biophysical Research Communications, 1980
- In vitro studies on the mode of action of the phorbol esters, potent tumor promoters: Part 1CRC Critical Reviews in Toxicology, 1980
- A new method for receptor autoradiography: [3H]Opioid receptors in rat brainBrain Research, 1979
- Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase systemBiochemical and Biophysical Research Communications, 1979
- Action of phorbol esters in cell culture: Mimicry of transformation, altered differentiation, and effects on cell membranesJournal of Supramolecular Structure, 1979
- Phorbol esters stimulate DNA synthesis and ornithine decarboxylase activity in mouse epidermal cell culturesNature, 1976