Development of a novel biocompatible polymer system for extended drug release in a next‐generation drug‐eluting stent
- 15 October 2007
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research Part A
- Vol. 85A (4), 1064-1071
- https://doi.org/10.1002/jbm.a.31664
Abstract
Drug-eluting stents have proven superior to bare metal stents with lower restenosis rates. Local delivery of drugs from these stents is achieved in most cases with the help of biostable polymer coatings. However, since the polymer coating remains in the body well after all the drug is released, patients can potentially develop hypersensitivity to these polymers—leading to complications such as late-stent thrombosis. It is therefore important that the polymers are designed to be biocompatible and well tolerated by the body. The polymer coatings are also expected to be robust and provide good control over elution of the desired drug. This paper describes the development of a unique, proprietary polymer blend system, specially designed to meet these requirements. Mutually compatible, free-radical-initiated elastomeric polymers were designed to provide a robust coating and offer a steady, sustained release of the highly hydrophobic drug zotarolimus over an extended period. The polymer blend system is also well tolerated by the hydrophilic environment in vivo, as demonstrated through porcine studies. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008Keywords
This publication has 21 references indexed in Scilit:
- Drug-eluting stents: Beyond the hyperboleAdvanced Drug Delivery Reviews, 2006
- Failure to Retrieve Undeployed Paclitaxel-Eluting Coronary StentsThe American Journal of Cardiology, 2006
- Sirolimus and Paclitaxel on Polymer-Based Drug-Eluting StentsJournal of the American College of Cardiology, 2006
- Hypersensitivity Cases Associated With Drug-Eluting Coronary StentsJournal of the American College of Cardiology, 2006
- Technology Insight: an overview of research in drug-eluting stentsNature Clinical Practice Cardiovascular Medicine, 2005
- Cypher Versus Taxus: Are There Differences?Journal of Interventional Cardiology, 2005
- Update on drug-eluting coronary stentsExpert Review of Cardiovascular Therapy, 2005
- ABT-578-Eluting StentsHerz, 2004
- Drug-eluting stents in vascular interventionThe Lancet, 2003
- Pathobiologic Responses to StentingThe American Journal of Cardiology, 1998