Human Cytomegalovirus Latency and Reactivation in Allogeneic Hematopoietic Stem Cell Transplant Recipients
Open Access
- 28 May 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Microbiology
- Vol. 10, 1186
- https://doi.org/10.3389/fmicb.2019.01186
Abstract
Human cytomegalovirus (HCMV) reactivation is a major infectious cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). HCMV is a ubiquitous beta-herpesvirus which asymptomatically infects immunocompetent individuals but establishes lifelong latency, with the potential to reactivate to a life-threatening productive infection when the host immune system is suppressed or compromised. Opportunistic HCMV reactivation is the most common viral complication following engraftment after HSCT and is associated with a marked increase in non-relapse mortality, which appears to be linked to complex effects on post-transplant immune recovery. This minireview explores the cellular sites of HCMV latency and reactivation in HSCT recipients and provides an overview of the risk factors for HCMV reactivation post-HSCT. The impact of HCMV in shaping post-transplant immune reconstitution and its relationship with patient outcomes such as relapse and graft-versus-host disease will be discussed. Finally, we survey current and emerging strategies to prevent and control HCMV reactivation in HSCT recipients, with recent developments including adoptive T cell therapies to accelerate HCMV-specific T cell reconstitution and new anti-HCMV drug therapy for HCMV reactivation after HSCT.Keywords
Funding Information
- University of Sydney
- Cancer Institute NSW
This publication has 222 references indexed in Scilit:
- Efficient Human Cytomegalovirus Reactivation Is Maturation Dependent in the Langerhans Dendritic Cell Lineage and Can Be Studied using a CD14+Experimental Latency ModelJournal of Virology, 2012
- Inhibition of Inflammatory Interleukin-6 Activity via Extracellular Signal-Regulated Kinase–Mitogen-Activated Protein Kinase Signaling Antagonizes Human Cytomegalovirus Reactivation from Dendritic CellsJournal of Virology, 2011
- Experimental human cytomegalovirus latency in CD14+monocytesProceedings of the National Academy of Sciences of the United States of America, 2010
- Impact of donor CMV status on viral infection and reconstitution of multifunction CMV-specific T cells in CMV-positive transplant recipientsBlood, 2009
- How we treat cytomegalovirus in hematopoietic cell transplant recipientsBlood, 2009
- The Effect of Single and Combined Activating Killer Immunoglobulin-like Receptor Genotypes on Cytomegalovirus Infection and Immunity after Hematopoietic Cell TransplantationTransplantation and Cellular Therapy, 2009
- Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individualsClinical and Experimental Immunology, 2009
- Expansion of Human Cytomegalovirus (HCMV) Immediate-Early 1-Specific CD8+T Cells and Control of HCMV Replication after Allogeneic Stem Cell TransplantationJournal of Virology, 2008
- Bone-marrow-derived mesenchymal stem cells as a target for cytomegalovirus infection: Implications for hematopoiesis, self-renewal and differentiation potentialVirology, 2007
- Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjectsThe Journal of Experimental Medicine, 2005