Vitamin D Levels and Lipid Response to Atorvastatin

Abstract

Adequate vitamin D levels are necessary for good vascular health. 1,25-dihydroxycholecalciferol activates CYP3A4, an enzyme of the cytochrome P450 system, which metabolizes atorvastatin to its main metabolites. The objective of this study was to evaluate the response of cholesterol and triglycerides to atorvastatin according to vitamin D levels. Sixty-three patients with acute myocardial infarction treated with low and high doses of atorvastatin were included. Levels of total cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol were measured at baseline and at 12 months of follow-up. Baseline levels of 25-hydroxyvitamin D (25-OHD) were classified as deficient (30 nmol/L), insufficient (30–50 nmol/L), and normal (50 nmol/L). In patients with 25-OHD nmol/L, there were no significant changes in levels of total cholesterol ( mg/dL versus mg/dL), triglycerides ( mg/dL versus mg/dL), and LDL cholesterol ( mg/dL versus 92 mg/dL); whereas patients with insufficient (30–50 nmol/L) and normal vitamin D (50 nmol/L) had a good response to atorvastatin. We suggest that vitamin D concentrations 30 nmol/L may be required for atorvastatin to reduce lipid levels in patients with acute myocardial infarction.