Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin
Open Access
- 14 October 2009
- journal article
- research article
- Published by Ferrata Storti Foundation (Haematologica) in Haematologica
- Vol. 95 (3), 505-508
- https://doi.org/10.3324/haematol.2009.013136
Abstract
Expression of hepcidin, the key hormone governing iron transport, is reduced by anemia in a manner which appears dependent on increased bone marrow activity. The temporal associations between plasma hepcidin and other iron parameters were examined in healthy humans after erythropoietin administration and venesection. Profound hepcidin suppression appeared abruptly 24 hours after subcutaneous erythropoietin (P=0.003), and was near maximal at onset, with peak (mid-afternoon) levels reduced by 73.2%, gradually recovering over the following two weeks. Minor changes in circulating iron, soluble transferrin receptor and growth differentiation factor-15 were observed after the reduction in hepcidin. Similar but more gradual changes in these parameters were observed after reducing hematocrit by removal of 250 mL blood. These human studies confirm the importance of a rapidly responsive marrow–hepcidin axis in regulating iron supply in vivo, and suggest that this axis is regulated by factors other than circulating iron, soluble transferrin receptor or growth differentiation factor-15.Keywords
This publication has 25 references indexed in Scilit:
- Plasma hepcidin levels are elevated but responsive to erythropoietin therapy in renal diseaseKidney International, 2009
- Molecular Control of Iron TransportJournal of the American Society of Nephrology, 2007
- Suppression of hepcidin during anemia requires erythropoietic activityBlood, 2006
- Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell‐line HepG2 induced by thalassaemic seraBritish Journal of Haematology, 2006
- Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPSBlood, 2005
- Hepcidin in iron overload disordersBlood, 2005
- Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its InternalizationScience, 2004
- Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase proteinBlood, 2003
- The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammationJCI Insight, 2002
- FERROKINETICS IN NORMAL PERSONS AND IN PATIENTS HAVING VARIOUS ERYTHROPOIETIC DISORDERS 1JCI Insight, 1951