Anomalous phosphorylated neurofilament aggregations in central and peripheral axons of hens treated with tri‐Ortho‐cresyl phosphate (TOCP)
- 1 November 1992
- journal article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 33 (3), 455-460
- https://doi.org/10.1002/jnr.490330311
Abstract
Previous biochemical studies demonstrated a dramatic increase in phosphorylation of cytoskeletal proteins that occurs early in organophosphorus ester‐induced delayed neurotoxicity (OPIDN). In this report we present immunohistochemical evidence that there is anomalous aggregation of phosphorylated neurofilaments within central and peripheral axons following organophosphate exposure. The morphology, location, and time of appearance of these aggregations are consistent with the hypothesis that the aberrant phosphorylation of cytoskeletal elements is an antecedent to the focal axonal swelling and degeneration characteristic of OPIDN. © Wiley‐Liss, Inc.Keywords
This publication has 20 references indexed in Scilit:
- Mechanisms of Organophosphorus Ester-Induced Delayed Neurotoxicity: Type I and Type IIAnnual Review of Pharmacology and Toxicology, 1990
- The transport and assembly of the axonal cytoskeleton.The Journal of cell biology, 1989
- Neurofilament protein phosphorylation - where, when and whyTrends in Neurosciences, 1988
- Calcium and calmodulin stimulated in vitro phosphorylation of rooster brain tubulin and MAP-2 following a single oral dose of tri-o-cresyl phosphateBrain Research, 1986
- Multiple fates of newly synthesized neurofilament proteins: evidence for a stationary neurofilament network distributed nonuniformly along axons of retinal ganglion cell neurons.The Journal of cell biology, 1986
- Pathogenesis of experimental giant neurofilamentous axonopathies: A unified hypothesis based on chemical modification of neurofilamentsBrain Research Reviews, 1985
- THE PATTERN OF RECOVERY OF AXONS IN THE NERVOUS SYSTEM OF RATS FOLLOWING 2,5-HEXANEDIOL INTOXICATION: A QUESTION OF RHEOLOGY?Neuropathology and Applied Neurobiology, 1982
- Organophosphorus Ester-Induced Delayed NeurotoxicityAnnual Review of Pharmacology and Toxicology, 1981
- THE TOXIC EFFECTS OF TRI-ORTHO-CRESYL PHOSPHATE ON THE NERVOUS SYSTEM: AN EXPERIMENTAL STUDY IN HENSJournal of Neurology, Neurosurgery & Psychiatry, 1954
- Pharmacological and Chemical Studies of the Cause of So-Called Ginger Paralysis: A Preliminary ReportPublic Health Reports (1896-1970), 1930