Ultrasonic vocalizations in mouse models for speech and socio-cognitive disorders: insights into the evolution of vocal communication
Open Access
- 23 June 2010
- journal article
- review article
- Published by Wiley in Genes, Brain and Behavior
- Vol. 10 (1), 17-27
- https://doi.org/10.1111/j.1601-183x.2010.00610.x
Abstract
Comparative analyses used to reconstruct the evolution of traits associated with the human language faculty, including its socio-cognitive underpinnings, highlight the importance of evolutionary constraints limiting vocal learning in non-human primates. After a brief overview of this field of research and the neural basis of primate vocalizations, we review studies that have addressed the genetic basis of usage and structure of ultrasonic communication in mice, with a focus on the gene FOXP2 involved in specific language impairments and neuroligin genes (NL-3 and NL-4) involved in autism spectrum disorders. Knockout of FoxP2 leads to reduced vocal behavior and eventually premature death. Introducing the human variant of FoxP2 protein into mice, in contrast, results in shifts in frequency and modulation of pup ultrasonic vocalizations. Knockout of NL-3 and NL-4 in mice diminishes social behavior and vocalizations. Although such studies may provide insights into the molecular and neural basis of social and communicative behavior, the structure of mouse vocalizations is largely innate, limiting the suitability of the mouse model to study human speech, a learned mode of production. Although knockout or replacement of single genes has perceptible effects on behavior, these genes are part of larger networks whose functions remain poorly understood. In humans, for instance, deficiencies in NL-4 can lead to a broad spectrum of disorders, suggesting that further factors (experiential and/or genetic) contribute to the variation in clinical symptoms. The precise nature as well as the interaction of these factors is yet to be determined.Keywords
This publication has 120 references indexed in Scilit:
- Human-specific transcriptional regulation of CNS development genes by FOXP2Nature, 2009
- Females alter their song when challenged in a sex-role reversed bird speciesBehavioral Ecology and Sociobiology, 2009
- A Humanized Version of Foxp2 Affects Cortico-Basal Ganglia Circuits in MiceCell, 2009
- Ultrasonic vocalizations: A tool for behavioural phenotyping of mouse models of neurodevelopmental disordersNeuroscience & Biobehavioral Reviews, 2009
- The Neural Control of Vocalization in Mammals: A ReviewJournal of Voice, 2009
- Impaired Synaptic Plasticity and Motor Learning in Mice with a Point Mutation Implicated in Human Speech DeficitsCurrent Biology, 2008
- Reduced ultrasonic vocalizations in vasopressin 1b knockout miceBehavioural Brain Research, 2008
- Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cellsProceedings of the National Academy of Sciences of the United States of America, 2008
- Avian brains and a new understanding of vertebrate brain evolutionNature Reviews Neuroscience, 2005
- Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autismNature Genetics, 2003