Polymorphic form IV of olanzapine
- 31 October 2011
- journal article
- Published by International Union of Crystallography (IUCr) in Acta Crystallographica Section C Crystal Structure Communications
- Vol. 67 (11), o461-o463
- https://doi.org/10.1107/s0108270111043952
Abstract
2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine, C(17)H(20)N(4)S, commonly known as olanzapine, is a psychotropic agent that belongs to the thienobenzodiazepine class of drugs. A new polymorph form IV was obtained upon attempted cocrystallization with nicotinamide in a 1:1 ratio from an ethyl acetate solution. Two butterfly-like molecules form centrosymmetric dimers stabilized by weak C-H···π interactions between the 4-methylpiperazin-1-yl fragment and the benzene/thiophene aromatic system. Form IV consists of a herringbone arrangement of dimers, whereas the previously reported form II has parallel dimers. Both crystal structures are sustained by an N-H···N hydrogen bond.Keywords
This publication has 15 references indexed in Scilit:
- New polymorphs of curcuminChemical Communications, 2011
- New polymorphs of isonicotinamide and nicotinamideChemical Communications, 2010
- The Top Prescription Drugs of 2009 in the US: CNS Therapeutics Rank among Highest GrossingACS Chemical Neuroscience, 2010
- Structure validation in chemical crystallographyActa crystallographica. Section D, Structural biology, 2009
- A short history of SHELXActa Crystallographica Section A Foundations of Crystallography, 2007
- Investigating the latent polymorphism of maleic acidChemical Communications, 2005
- Olazipinium nicotinateActa Crystallographica Section E Structure Reports Online, 2005
- 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-b][1,5]benzodiazepine methanol solvate monohydrateActa Crystallographica Section E Structure Reports Online, 2003
- Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural RelationshipsCrystal Growth & Design, 2003
- Patterns in Hydrogen Bonding: Functionality and Graph Set Analysis in CrystalsAngewandte Chemie-International Edition, 1995