Engagement of NKp30 on Vδ1 T cells induces the production of CCL3, CCL4, and CCL5 and suppresses HIV-1 replication
- 26 April 2012
- journal article
- Published by American Society of Hematology in Blood
- Vol. 119 (17), 4013-4016
- https://doi.org/10.1182/blood-2011-11-390153
Abstract
Natural cytotoxicity receptors (NCRs) were originally identified as specific natural killer cell activating receptors that, on binding to their endogenous ligands, trigger the killing of tumor cell targets. We recently described the differentiation of a novel subset of NCR(+) Vδ1 T cells characterized by a remarkably high cytolytic potential against cancer cells. Here we demonstrate that the engagement of NKp30, one of the NCRs expressed de novo on Vδ1 T cells after stimulation, triggers the production of high levels of CCL3/MIP-1α, CCL4/ MIP-1β, and CCL5/RANTES but not of CXCL12/SDF-1. In turn, this NKp30-induced secretion of cc-chemokines is able to significantly suppress the replication of a CCR5 tropic strain of HIV-1 in CD4(+)/CCR5(+) infected PM1 cell lines. This experimental evidence disclosing an unanticipated antiviral function of NCR(+) Vδ1 T cells opens new avenues for understanding the pathogenic role and for manipulating the function of γδ T cells in HIV-1 infection.Keywords
This publication has 24 references indexed in Scilit:
- γδ T Cell Immune Manipulation during Chronic Phase of Simian HIV Infection Confers Immunological BenefitsPublished by The American Association of Immunologists ,2009
- Immune activation and inflammation in HIV‐1 infection: causes and consequencesThe Journal of Pathology, 2007
- Microbial translocation is a cause of systemic immune activation in chronic HIV infectionNature Medicine, 2006
- Migration of Vδ1 and Vδ2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1–infected patients: competition by HIV-1 TatBlood, 2004
- Activating Receptors and Coreceptors Involved in Human Natural Killer Cell-Mediated CytolysisAnnual Review of Immunology, 2001
- γδ Cells: A Right Time and a Right Place for a Conserved Third Way of ProtectionAnnual Review of Immunology, 2000
- Identification of a major co-receptor for primary isolates of HIV-1Nature, 1996
- HIV-1 Entry Cofactor: Functional cDNA Cloning of a Seven-Transmembrane, G Protein-Coupled ReceptorScience, 1996
- Identification of RANTES, MIP-1α, and MIP-1β as the Major HIV-Suppressive Factors Produced by CD8 + T CellsScience, 1995
- T cell receptor γδ repertoire in HIV‐1‐infected individualsEuropean Journal of Immunology, 1994