Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners
- 3 June 2009
- journal article
- review article
- Published by Springer Science and Business Media LLC in Seminars in Immunopathology
- Vol. 31 (2), 207-221
- https://doi.org/10.1007/s00281-009-0157-4
Abstract
LIGHT and herpes virus entry mediator (HVEM) comprise a ligand–receptor pair in the tumor necrosis factor superfamily. These molecules play an important role in regulating immunity, particularly in the intestinal mucosa. LIGHT also binds the lymphotoxin β receptor, and HVEM can act as a ligand for immunoglobulin family molecules, including B- and T-lymphocyte attenuator, which suppresses immune responses. Complexity in this pivotal system arises from several factors, including the non-monogamous pairing of ligands and receptors, and reverse signaling or the ability of some ligands to serve as receptors. As a result, recognition events in this fascinating network of interacting molecules can have pro- or anti-inflammatory consequences. Despite complexity, experiments we and others are carrying out are establishing rules for understanding when and in what cell types these molecules contribute to intestinal inflammation.Keywords
This publication has 103 references indexed in Scilit:
- Unconventional ligand activation of herpesvirus entry mediator signals cell survivalProceedings of the National Academy of Sciences of the United States of America, 2009
- From the diet to the nucleus: Vitamin A and TGF-β join efforts at the mucosal interface of the intestineSeminars in Immunology, 2009
- The TNF Superfamily-2008Cytokine & Growth Factor Reviews, 2008
- A crucial role for HVEM and BTLA in preventing intestinal inflammationThe Journal of Experimental Medicine, 2008
- Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17–producing T cell responsesNature Immunology, 2007
- Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acidThe Journal of Experimental Medicine, 2007
- A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanismThe Journal of Experimental Medicine, 2007
- LIGHT Signals Directly to Intestinal Epithelia to Cause Barrier Dysfunction via Cytoskeletal and Endocytic MechanismsGastroenterology, 2007
- BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1Nature Immunology, 2003
- Transgenic Mice Expressing a TruncatedPeromyscus leucopusTNF-α Gene Manifest an Arthritis Resembling Ankylosing SpondylitisJournal of Interferon & Cytokine Research, 1998