miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151
- 15 August 2014
- journal article
- Published by Springer Science and Business Media LLC in Tumor Biology
- Vol. 35 (11), 11367-11373
- https://doi.org/10.1007/s13277-014-2471-2
Abstract
We aimed to study the post-translational regulation of CD151 by the microRNA miR-152. CD151 is highly expressed in gastric cancer (GC) and has been shown to accelerate GC by enhancing invasion and metastasis; however, its regulation is still unclear. Our results showed decreased expression of miR-152 in GC tissue samples and cell lines. In addition, miR-152 complementation significantly inhibits both the proliferation and motility of GC cells. CD151 was found to be a target of miR-152, and overexpression of CD151 attenuated the suppressive effect of miR-152. Our findings highlight an essential role of miR-152 in the regulation of proliferation and motility of GC cells and suggest a potential application of miR-152 in GC treatment.Keywords
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