Membrane rafting: From apical sorting to phase segregation
- 28 December 2009
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 584 (9), 1685-1693
- https://doi.org/10.1016/j.febslet.2009.12.043
Abstract
In this review we describe the history of the development of the raft concept for membrane sub-compartmentalization. From its early beginnings as a mechanism for apical sorting in epithelial cells the concept has evolved to a general principle for membrane organisation. After a shaky start with crude methodology based on detergent extraction the field has become increasingly sophisticated, employing a host of different methods that support the existence of dynamic raft domains in membranes. These are composed of fluctuating nanoscale assemblies of sphingolipid, cholesterol and proteins that can be stabilized to coalesce, forming platforms that function in membrane signalling and trafficking. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (SFB/TR13-04 & SP1175)
- EU FP6 “PRISM”
This publication has 124 references indexed in Scilit:
- Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signallingThe EMBO Journal, 2009
- Phase diagrams and lipid domains in multicomponent lipid bilayer mixturesBiochimica et Biophysica Acta (BBA) - Biomembranes, 2008
- A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorStructure, 2008
- Protein area occupancy at the center of the red blood cell membraneProceedings of the National Academy of Sciences, 2008
- Structures and physiological roles of 13 integral lipids of bovine heart cytochrome c oxidaseThe EMBO Journal, 2007
- Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesiclesProceedings of the National Academy of Sciences, 2007
- Epidermal growth factor receptor tyrosine kinase is modulated by GM3 interaction with N-linked GlcNAc termini of the receptorProceedings of the National Academy of Sciences, 2006
- Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshworkThe EMBO Journal, 2006
- UCSF Chimera?A visualization system for exploratory research and analysisJournal of Computational Chemistry, 2004
- Caveolin, a protein component of caveolae membrane coatsCell, 1992