Possible role of gap junction intercellular channels and connexin 43 in satellite glial cells (SGCs) for preservation of human spiral ganglion neurons
Open Access
- 17 November 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cell and tissue research
- Vol. 355 (2), 267-278
- https://doi.org/10.1007/s00441-013-1735-2
Abstract
Human spiral ganglion (SG) neurons show remarkable survival properties and maintain electric excitability for a long time after complete deafness and even separation from the organ of Corti, features essential for cochlear implantation. Here, we analyze and compare the localization and distribution of gap junction (GJ) intercellular channels and connexin 43 (Cx43) in cells surrounding SG cell bodies in man and guinea pig by using transmission electron microscopy and confocal immunohistochemistry. GJs and Cx43 expression has been recognized in satellite glial cells (SGCs) in non-myelinating sensory ganglia including the human SG. In man, SG neurons can survive as mono-polar or “amputated” cells with unbroken central projections following dendrite degeneration and consolidation of the dendrite pole. Cx43-mediated GJ signaling between SGCs is believed to play a key role in this “healing” process and could explain the unique preservation of human SG neurons and the persistence of cochlear implant function.Keywords
This publication has 47 references indexed in Scilit:
- Distribution of P75 neurotrophin receptor in adult human cochlea—an immunohistochemical studyCell and tissue research, 2012
- Expression of TrkB and BDNF in human cochlea—an immunohistochemical studyCell and tissue research, 2011
- Emerging Importance of Neuron-Satellite Glia Interactions within Trigeminal Ganglia in Craniofacial Pain~!2009-08-31~!2009-11-23~!2010-05-07~!The Open Pain Journal, 2010
- Evidence for a Role of Connexin 43 in Trigeminal Pain Using RNA Interference In VivoJournal of Neurophysiology, 2008
- The Effect of Organ of Corti Loss on Ganglion Cell Survival in HumansOtology & Neurotology, 2006
- Enhanced Connexin 43 immunoreactivity in penumbral areas in the human brain following ischemiaGlia, 2006
- Multichannel Cochlear Implants: Relation of Histopathology to PerformanceThe Laryngoscope, 2006
- Increased Apoptosis and Inflammation after Focal Brain Ischemia in Mice Lacking Connexin43 in AstrocytesThe American Journal of Pathology, 2004
- Expression of the connexin43- and connexin45-encoding genes in the developing and mature mouse inner earCell and tissue research, 2004
- Gap junctions in cultured astrocytes: Single-channel currents and characterization of channel-forming proteinNeuron, 1991