Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus Infection
- 1 March 1997
- journal article
- Published by American Academy of Pediatrics (AAP)
- Vol. 99 (3), 409-414
- https://doi.org/10.1542/peds.99.3.409
Abstract
Objective. To determine whether newborn cranial computed tomographic (CT) scan abnormalities predict an adverse neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection and to examine the association between clinical findings at birth and imaging abnormalities. Methods. The data from 56 children with symptomatic congenital CMV infection who underwent cranial CT scans as newborns and were enrolled in a long-term follow-up study were analyzed. The incidence of sequelae was compared between the groups of children with normal and abnormal imaging studies. The relationship between CT scan results and other newborn findings was also examined. Results. Abnormal CT scans were noted in 70% of subjects; intracerebral calcification was the most frequent finding. Most of the children with an abnormal newborn CT scan (90%) developed at least one sequela, compared with 29% of those with a normal study. Only 1 child with a normal CT scan had an IQ Conclusion. In neonates with symptomatic congenital CMV infection, a cranial CT scan is a good predictor of an adverse neurodevelopmental outcome. In addition, newborn clinical and laboratory findings did not predict neuroradiographic abnormalities in neonates with symptomatic congenital CMV infection.Keywords
This publication has 17 references indexed in Scilit:
- Interobserver and Intraobserver Variability in Interpretation of Lumbar Disc AbnormalitiesSpine, 1995
- The Outcome of Congenital Cytomegalovirus Infection in Relation to Maternal Antibody StatusNew England Journal of Medicine, 1992
- Symptomatic congenital cytomegalovirus infectionThe Pediatric Infectious Disease Journal, 1992
- Infectious Diseases Society of America and Centers for Disease Control: Summary of a Workshop on Surveillance for Congenital Cytomegalovirus DiseaseClinical Infectious Diseases, 1991
- Outcome in Children With Symptomatic Congenital Cytomegalovirus InfectionJournal of Child Neurology, 1990
- Early clinical manifestations and intellectual outcome in children with symptomatic congenital cytomegalovirus infectionThe Journal of Pediatrics, 1987
- Congenital and postnatally acquired cytomegalovirus infections: Long-term follow-upThe Journal of Pediatrics, 1984
- Human Cytomegalovirus Infection and Disorders of the Nervous SystemArchives of Neurology, 1984
- Congenital Cytomegalovirus Infection: A Fifteen Year PerspectiveThe Journal of Infectious Diseases, 1971