INTACS for Keratoconus

Abstract

INTACS are two, arc like, PMMA segments which were designed to be surgically inserted into the deep corneal stroma to flatten the central cornea. Their original application was for the refractive correction of mild myopia (−1 to −3D). However, because of the superior accuracy and familiarity with the excimer laser by refractive surgeons, they are rarely used for this indication, except in patients with forme fruste keratoconus or extremely thin corneas with less than 3D of Myopia (1,2). Dr. Joseph Colin in France first conceived of the concept of using INTACS to treat patients with keratoconus and published his first report on the safety and efficacy for this indication in 2001(3). At 1 year, all 10 patients he operated became contact lens tolerant and demonstrated an improvement in both uncorrected and best-corrected acuity (4). Since his pioneering work, corneal surgeons throughout the word have adopted this technology to treat patients with mild to moderate keratoconus who are contact lens intolerant and/or who desire a modest improvement in uncorrected and best-corrected visual acuity (5-14). In the United States 0.25mm, 0.275mm, 0.30mm, 0.325mm and 0.35mm segments are available for use. They are approved in the United States by the FDA under an Human Devise Exemption for compassionate therapeutic use. Outside of the United States .40mm and 0.45mm sized segments are also available. Competitive devices the Ferrara ring and the Keraring are also sold and marketed outside of the United States since they do not have FDA approval in the USA. The main difference between these two devices is that with INTACS the optical zone is approximately 7mm while the Ferrara and Kerarings have an optical zone of the order of 4.5 to 5mm. Recently Intacs SK was introduced outside of the United States. They have an optical zone of 6 mm and have a round design to minimize glare. They may be used to correct larger myopic and astigmatic refractive errors than INTACS because of their design and closer proximity to the visual axis(15)