Mechanisms of Hepatic Regeneration Following Portal Vein Embolization and Partial Hepatectomy: A Review
- 5 January 2007
- journal article
- review article
- Published by Wiley in World Journal of Surgery
- Vol. 31 (2), 367-374
- https://doi.org/10.1007/s00268-006-0526-2
Abstract
Portal vein embolization (PVE) improves outcome following major hepatectomy, and basic studies have presented evidence related to the mechanisms responsible for hepatic regeneration. Hemodynamic changes following PVE are similar to, but slightly different from, those of partial hepatectomy (PH) because arterial flow to the embolized lobe is preserved. However, the process of hepatic regeneration is essentially the same after both PVE and PH. A number of mediators are involved in PVE or PH-induced hepatic regeneration. These include inflammatory cytokines, vasoregulators, growth factors, eicosanoids, and various hormones. These mediators activate a complex network of signal transduction that promotes hepatic regeneration. A variety of conditions have been shown to modulate the function of these mediators and inhibit regeneration. These include biliary obstruction, diabetes, chronic ethanol consumption, malnutrition, gender, aging, and infection.This publication has 93 references indexed in Scilit:
- Inactivation of TGF-β signaling in hepatocytes results in an increased proliferative response after partial hepatectomyOncogene, 2005
- The influence of spleen size on liver regeneration after major hepatectomy in normal and early cirrhotic liverLiver International, 2005
- Ethanol Induces Redox‐Sensitive Cell‐Cycle Inhibitors and Inhibits Liver Regeneration After Partial HepatectomyAlcohol: Clinical and Experimental Research, 2002
- Lower Activity of CCAAT/Enhancer-Binding Protein and Expression of Cyclin E, but Not Cyclin D1, Activating Protein-1 and p21WAF1, after Partial Hepatectomy in Obstructive JaundiceBiochemical and Biophysical Research Communications, 2001
- Acute effects of partial hepatectomy on liver blood flow in the jaundiced ratJournal of Hepatology, 1993
- Effects of partial hepatectomy on hepatic insulinlike growth factor binding protein-1 expressionHepatology, 1992
- Decrease in Regeneration Capacity of Rat Liver after External Biliary DrainageEuropean Surgical Research, 1992
- Induction of hepatocyte mitosis in intact adult rat by interleukin-1 α and interleukin-6Life Sciences, 1991
- Tumor necrosis factor stimulates DNA synthesis in the liver of intact ratsBiochemical and Biophysical Research Communications, 1988
- The stimulation by epidermal growth factor (Urogastrone) of the growth of neonatal rat hepatocytes in primary tissue culture and its modulation by serum and associated pancreatic hormonesJournal of Cellular Physiology, 1980