5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c]- [1,4]benzodiazepin-10(11H)-ylcarbonyl)-3- chlorophenyl]benzamide (VPA-985): An Orally Active Arginine Vasopressin Antagonist with Selectivity for V2Receptors
- 16 June 1998
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 41 (14), 2442-2444
- https://doi.org/10.1021/jm980179c
Abstract
No abstract availableKeywords
This publication has 19 references indexed in Scilit:
- AbstractJournal of the American College of Cardiology, 1997
- Rat renal arcade segment expresses vasopressin-regulated water channel and vasopressin V2 receptor.JCI Insight, 1996
- Orally Active, Nonpeptide Vasopressin V2 Receptor Antagonists: A Novel Series of 1-[4-(Benzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepines and Related CompoundsJournal of Medicinal Chemistry, 1996
- Potent aquaretic agent. A novel nonpeptide selective vasopressin 2 antagonist (OPC-31260) in men.JCI Insight, 1993
- Biochemical and pharmacological properties of SR 49059, a new, potent, nonpeptide antagonist of rat and human vasopressin V1a receptors.JCI Insight, 1993
- Cloning of the Human Type‐2 Vasopressin Receptor GeneAnnals of the New York Academy of Sciences, 1993
- Radioligand binding studies reveal marked species differences in the vasopressin V1 receptor of rat, rhesus and human tissuesLife Sciences, 1992
- Molecular cloning of the receptor for human antidiuretic hormoneNature, 1992
- OPC-21268, an Orally Effective, Nonpeptide Vasopressin V1 Receptor AntagonistScience, 1991
- Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplicationJournal of Medicinal Chemistry, 1980