Systemic mirnas as potential biomarkers for malignancy
Open Access
- 23 May 2012
- journal article
- review article
- Published by Wiley in International Journal of Cancer
- Vol. 131 (10), 2215-2222
- https://doi.org/10.1002/ijc.27642
Abstract
MiRNAs are a class of short, endogenous, single‐stranded RNA molecules that play a role in the regulation of gene expression. They have been shown to modulate a number of cellular processes including cell differentiation, growth and apoptosis and as a result have been implicated in carcinogenesis. They are detectable in tumour tissue, and altered expression levels have been identified in various cancer types. Of interest, miRNAs have recently been detected and identified to be dysregulated in the circulation of patients with breast cancer. The fact that a minimally invasive test can distinguish the presence or absence of disease illustrates the immense potential these molecules hold as predictive markers. This review serves to identify those systemic miRNAs that are upregulated or downregulated in malignancy and how treatment impacts on their circulating levels. In addition, this review questions the source of these small molecules in the bloodstream and how they may possibly play a role in the future detection of cancer as either prognostic or predictive markers. © 147.Keywords
This publication has 59 references indexed in Scilit:
- Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screeningBritish Journal of Cancer, 2010
- Circulating microRNAs in plasma of patients with gastric cancersBritish Journal of Cancer, 2010
- Causes and consequences of microRNA dysregulation in cancerNature Reviews Genetics, 2009
- The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platformGynecologic Oncology, 2009
- Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersNature, 2008
- Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesCell Research, 2008
- RETRACTED: MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancerGynecologic Oncology, 2008
- Real-time PCR quantification of precursor and mature microRNAMethods, 2008
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- MicroRNA expression profiles classify human cancersNature, 2005